Prozac — generically known as fluoxetine — is a widely-used SSRI anti-depressant, considered to be #3 in sales in the U.S. In fact, with over 22 million prescriptions for generic formulations of fluoxetine filled in the United States in 2007, it’s almost as popular as marijuana (about 30 million regular users). There have been numerous books and songs written about Prozac, and even a few movies.


How Does Prozac Compare To Medical Marijuana?

Even though fluoxetine is an FDA-approved drug, it has a number of side effects, some of them potentially serious. And as Prozac is an FDA-approved anti-depressant, it’s pretty depressing that it’s been linked to numerous suicides and one high-profile mass murder.

Wikipedia says, “Sexual dysfunction is a common side effect with SSRIs. Specifically, side effects often include difficulty becoming aroused, erectile dysfunction, lack of interest in sex, and anorgasmia (inability to achieve orgasm). Genital anesthesia, loss of or decreased response to sexual stimuli, and ejaculatory anhedonia are also possible. Although usually reversible, these sexual side effects can last for months, years, or permanence after the drug has been completely withdrawn.”

PubMed says, “Older adults should not usually take fluoxetine on a daily basis because it is not as safe as other medications that can be used to treat the same conditions.”

We’ve taken the following information from Wikipedia and PubMed, and highlighted in bold green any side effects or uses that match those known for cannabis.

In general, if you’re using Prozac, you might consider trying a safer drug…like cannabis.

Trade Names: Prozac, Sarafem, Fontex, Rapiflux
Street Names: none
Generic NameFluoxetine

Some Typical Uses:

  • depression
  • obsessive-compulsive disorder
  • bulimia nervosa
  • panic disorder 
  • premenstrual dysphoric disorder

Common Side Effects:

  • nervousness
  • nausea
  • dry mouth
  • sore throat
  • drowsiness
  • weakness
  • uncontrollable shaking of a part of the body
  • loss of appetite
  • weight loss
  • changes in sex drive or ability
  • excessive sweating

Less Common Side Effects:

  • rash*
  • hives
  • fever
  • joint pain
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • difficulty breathing or swallowing
  • fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness
  • seeing things or hearing voices that do not exist (hallucinating)
  • seizures
* Serious rash complications included vasculitis and lupus-like syndrome. Death has been reported to occur in association with these systemic events.

3 Responses

  1. J.T. Chronic

    They have put me on every poision they make for depression and Prozac caused me to want to end my life! It is a poision that has killed. I dont know of anyone dieing from using cannabis. Cannabis has saved me a few times when things got out of controll in my head. For those of you who say Cannabis has no med. value are liers. With God as my wittness cannabis has kept me alive.

  2. lissa

    I just started taking Prozac and would gladly substitute that with cannabis if only Medi would pay for the medicine that I prefer to take. My appointment yesterday at the mental health clinic,I told the DR. of my wish that Medical would pay for my MMJ. Her list, of my Prescriptions had “MEDICAL MARIJUANA”,right on the top of the copy I was supposed to give to the pharmacist to fill. Wouldn`t it be wonderful have all my meds come in one trip to the Drug Store.I was busted with weed I grew legally in Calif last year. I tried to mail it to myself through UPS. They day the package came so did the New York State Police. Our country needs to get together to disband the DEA as they appear to be the ones stopping the schedule change for cannabis .As soon as I told the probation officer I had a place to live in Calif. I had my case transferred there and am happily medicating as needed ,with the permission of the Alameda County Probation Department, just like SB 420 was written. Kudos Alameda County and YEAH CALIFORNIA.

  3. Filmjunkie77

    I use cannabis regularly and am thinking about starting on Prozac for treatment of depression and an anxiety disorder. Is there any recent info on whether or not the combination of the two could be harmful or have adverse/negative effects?

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